Sam Gambhir brought together the field of cell and molecular biology with that of biomedical imaging to form the field of multimodality molecular imaging of living subjects. He developed and translated strategies for merging nuclear and optical sciences for improved cancer detection and management. These strategies include the imaging of gene and cell therapies through positron emission tomography (PET) and multimodality reporter gene technology. He also developed multimodality imaging agents for use in Raman optical imaging and photoacoustic molecular imaging for applications involving the brain, gastrointestinal tract, and the prostate. His approaches also use novel cell and molecular biology to force cancer cells to reveal themselves through both in vitro and in vivo diagnostics. His work has enabled hundreds of laboratories and companies around the world to utilize molecular imaging to study fundamental biological processes in both animals and humans.
Gambhir is the Virginia & D.K. Ludwig Professor of Cancer Research and the Chair of the Department of Radiology at the Stanford University School of Medicine, Stanford, CA, USA.